Projeto PRR

Sumário

Job Description:We are seeking an ambitious microbiologist to develop high impact pharmacomicrobiomics research. The researcher will lead studies on how drugs shape the human microbiome and how microbiome impact treatment outcomes, adverse events, and antimicrobial resistance development. Combining wet lab experiments, bioinformatic analysis, and creation of new predictive tools, the researcher will illuminate this critical intersection between microbiology, pharmacology, toxicology and precision medicine.Responsibilities:Lead wet lab experiments to analyze changes in the uro-genital microbiota induced by antimicrobials, therapeutics, and xenobiotics.Conduct bioinformatic investigations into drug-microbiome-host interactions and examine alterations in pharmacologic or toxicologic properties caused by the uro-genital microbiome, utilizing multi-omics data.Investigate role of microbiome in development of antimicrobial resistance and multidrug resistance.Conduct data analysis and interpretation to identify trends and patterns in Pharmacomicrobiomics data.Develop novel tools to predict Pharmacomicrobiomics outcomes and identify potential adverse events.Generate insights aimed at enhancing efficacy, minimizing adverse events, and addressing antimicrobial resistance.Stay up-to-date on cutting-edge methods and tools in Pharmacomicrobiomics.Collaborate with multidisciplinary teams to integrate microbiology, pharmacology, and toxicology data for precision medicine applications, with a particular emphasis on combating antimicrobial resistance.Engage in technology transfer initiatives.Contribute to the development of innovative strategies for combating antimicrobial resistance by leveraging insights from Pharmacomicrobiomics research.Supervise undergraduate and graduate students at master´s and PhD levels, and manage mentorship of junior researchers.Participate in grant writing and funding acquisition efforts to support ongoing research projects.Disseminate research findings through high-impact publications, patent filings, and presentations at conferences and public forums.Scientific profile:The scientific profile of the Assistant researcher in the field of pharmaceutical sciences with a focus on pharmacomicrobiomics and antimicrobial resistance should possess a robust scientific background bridging microbiology and pharmacology, coupled with proficiency in bioinformatic analysis. A comprehensive understanding of the human microbiome and its intricate interactions with pharmacological agents is fundamental. The candidate educational background should include a master’s degree in Microbiology, Pharmaceutical Sciences, Medicine, Pharmacology, Bioinformatics, Computational Biology or closely related field and PhD specialization on microbiome analysis, drug-microbe interactions, antibiotic resistance, genomic epidemiology, multi-omics integrative analysis or related field.Additionally, expertise in wet lab experimentation, next-generation sequencing, and bioinformatic tools for microbiome data analysis would be essential. The assistant researcher should have experience supporting the capacity in designing and conducting wet lab experiments to investigate drug-microbiome interactions, as well as to perform bioinformatic analysis to characterize these interactions. Experience tracking antimicrobial resistance evolution and resistance gene mobility is also important. Furthermore, the candidate should have a track record of collaborative research within multidisciplinary teams, as the role involves integrating microbiology, pharmacology, and toxicology data for precision medicine applications. Strong communication skills and the ability to disseminate research findings through publications and scientific presentations are also important aspects of the scientific profile for this research assistant position.Rationale:The recruitment of Assistant researcher in Pharmaceutical Sciences with focus in Pharmacomicrobiomics while being synergistic with many ongoing efforts, will catalyze growth of pharmacomicrobiomics research at UCIBIO/i4HB, generating new discoveries, funding, collaborations and scientific talent development in this high-potential space. This work falls mainly under the UCIBIO thematic line of "Biological and Biomolecular Interactions”. This profile complements UCIBIO´s existing expertise in microbiome research, bioinformatics, multi-omics analysis, and drug discovery, with expected results fueling new high-impact collaborations between UCIBIO groups in areas like AMR, precision medicine, and biotechnology. Moreover, its specialized knowledge can add value to many ongoing and new projects at UCIBIO in the nexus between microbiology and pharmaceuticals. They will help attract new funding and partnerships to UCIBIO in the emerging pharmacomicrobiome space.