PRR Project

Summary

iNOVA4Health FCT Research Unit is seeking a highly qualified and motivated Assistant Researcher for a position specializing in Lipid Biology. The successful candidate will be responsible for conducting cutting-edge research in the areas of Lipid Biology with a specific focus on Lysosome function. Key tasks include developing assays to monitor lysosome and autophagy function in cell models, exploring novel biomarkers and therapeutic targets for the treatment of atherosclerosis, and investigating the role of lipid catabolism in acquired and inherited lysosomal disorders. The researcher will contribute to the advancement of scientific knowledge and the development of innovative solutions in the field.Key Responsibilities:1) Innovative Research: Developing assays to monitor organelle dysfunction in cell models of atherosclerosis, with particular focus on lysosome and autophagy function. Exploring novel biomarkers and therapeutic targets for atherosclerosis by uncovering the molecular mechanisms associated with this pathology. Investigating the role of lysosomal lipid catabolism in acquired and inherited lysosomal disorders through different lipidomic analyses.2) Education and Training Programs: Developing education and training programs in Lysosome Biology at the graduate levels particularly master and PhD courses.3) Collaborative Research: Collaborate with internal teams and external partners, including interdisciplinary groups, to advance research projects. Participate in joint ventures that bridge the gap between basic science and translational medicine.4) Data Analysis and Reporting: Analyse experimental data using statistical methods. Prepare and present research findings at internal meetings and scientific conferences. Contribute to the writing of research papers for publication in high impact peer-reviewed journals.5) Mentorship and Supervision: Mentor and supervise junior researchers and students providing guidance on research projects and assisting with their academic and professional development.6) Funding: Contribute to the development of research proposals and funding applications.Scientific Profile:1) Ph.D. in Biomedicine or  related areas  with a strong focus on Lysosome and Lipid Biology.2)Proven expertise in the development of assays to monitor lysosome and autophagy function in models of diseases associated with dysfunction of the lysosomal compartment, with a track record of successful funded projects.3) Extensive knowledge of the molecular mechanisms of lysosomal dysfunction and lipid catabolism, including published work in the field.4) Proficiency in utilizing animal and cell models of acquired and inherited lysosomal diseases, as well as lipid quantification techniques (e.g., colorimetric methods, HPLC and LC-MS/MS).5) Strong publication record in reputable scientific journals, demonstrating the ability to contribute novel insights to the field.6) Experience in supervising and co-supervising students.7) Ability to work independently as well as part of a team.8) Strong communication and interpersonal skills.Rationale for Hiring:The recruitment for this position aligns with the strategic goals of iNOVA4Health to advance research excellence in Lipid Biology in relation to cardiovascular diseases. The intersection of lysosome and lipid biology represents a burgeoning area of scientific exploration with promising applications in biomarker and drug discovery. The expertise of the successful candidate will significantly contribute to ongoing research projects and strengthen our institutional capabilities in these critical areas. Furthermore, the hire will enhance collaboration with external partners, foster academic-industry relationships, and contribute to the training of the next generation of researchers in Lipid Biology. This position reflects our commitment to innovation and scientific leadership, positioning iNOVA4Health at the forefront of advancements in Lipid Biology and related disciplines.