PRR Project

Summary

The NOVA Institute for Medical Systems Biology (NIMSB) will hire a skilled and motivated Assistant Researcher with a strong background in Stem Cell Technologies. The successful candidate will lead technological development and innovative research projects focused on using stem cells, organoids and other micro-physiological systems to advance our understanding and capabilities in disease modelling. Key Responsibilities:1) Patient-Derived Disease Models: Develop and refine patient-derived micro-physiological disease models, using human induced Pluripotent Stem Cell (iPSC) reprogramming, including: collection, expansion and curation in a biobank of patient cell samples; generation and characterization of iPSCs from patients and healthy donors for disease modelling; and development of organoids and organ-on-a-chip models that replicate the disease state at a tissue level, allowing for the study of disease mechanisms and the testing of therapeutic strategies in a controlled, patient-specific context.2) CRISPR/Cas9 Gene Editing: Establish gene editing protocols for knock-in and knock-out modifications in iPSCs derived from patients, designing and executing gene editing projects to understand the genetic underpinnings of specific diseases and to develop potential genetic therapies.3) Development of Single-Cell Multi-Omics Application of single-cell multi-omics analytical approaches to stem cells and organoids to uncover the cellular heterogeneity and molecular mechanisms underlying disease development.4) Education and Training Programs: Developing education and training programs in stem cells and organoids, aiming to prepare the next generation of researchers and healthcare workers in medical systems biology concepts5) Collaborative Research and Innovation Programs: Promote interdisciplinary collaboration and international networks to spearhead research and innovation programs. This involves forming and leading collaborations with NOVA Institutes, affiliated hospitals, and international partners to advance the development of early diagnostics and therapeutic solutions.6) Data Analysis and Reporting: Analyse experimental data using statistical methods. Prepare and present research findings at internal meetings and scientific conferences. Contribute to the writing of research papers for publication in high-impact peer-reviewed journals.7) Mentorship and Supervision: Mentor and supervise junior researchers and students. Provide guidance in experimental design, data analysis, and scientific writing.8) Funding: Contribute to the development of research proposals and funding applications. Scientific Profile:1) PhD in Cell Biology, Developmental Biology, or a related field.2) Minimum of 10 years postdoctoral experience in development biology and stem cells technologies.3) Demonstrated experience with tissue culture, especially the cultivation and differentiation of stem cells.4) Proficiency in advanced molecular biology techniques, including but not limited to qRT-PCR, and gene editing tools.5) Demonstrated experience in generation of human induced Pluripotent Stem Cell (iPSC).6) Proficiency in CRISPR/Cas9 gene editing tools.7) Publication record in stem cells, regenerative medicine, or related disciplines.8) Excellent analytical and problem-solving skills.9) Ability to work independently as well as part of a team.10) Strong communication and interpersonal skills. Rationale for Hiring:The field of Stem Cell Technologies is rapidly advancing, with the use of iPSCs and CRISPR/Cas9 tools, and the development of complex human organoids promising great clinical translational potential. Hiring an Assistant Researcher with expertise in this area is crucial for NIMSB to stay competitive and innovative in the global research landscape. The Assistant Researcher will be assigned a variety of critical tasks that leverage an expected extensive experience in stem cell research, gene-editing, and organoid technology. These tasks are designed to align with NIMSB’s mission of pioneering excellent interdisciplinary research in systems biology for medical innovation and precision medicine. By integrating the use of advanced stem cell technologies and complex human organoids or other micro-physiological systems, the Assistant Researcher will push the boundaries of current knowledge and contribute to the development of cutting-edge therapies treatments for a variety of diseases, leading to significant improvements in patient outcomes. This strategic hire will strengthen NIMSB research capacity, enable new collaborative projects, secure research funding, and enhance the institutional reputation as a leader in systems biology, particularly in stems cell and regenerative medicine research.