PRR Project

Summary

Job Description:Highly motivated and experienced Assistant Researcher with a strong background in structural biology of proteins, particularly in X-ray crystallography, biochemistry, biophysics and X-ray fluorescence imaging, moreover with knowledge and experience in SAXS and cryo-electron microscopy.  With a specific focus on studying the molecular mechanisms  associated with the cellular response against oxidative stress. This role involves leading innovative research projects aimed at unraveling the molecular mechanisms, encompassing enzymatic and non-enzymatic pathways, employed by bacteria in response to external mechanisms, with the goal to develop novel strategies aimed to protect organisms from stress conditions, namely radiation. Key Responsibilities: 1) Design and conduct cutting-edge research on structural biology area of proteins, with an emphasis on the area of X-ray crystallography, SAXS, cryo-electron microscopy, biochemistry and X-ray fluorescence imaging. 2) Develop and apply structural biology methodologies to investigate fundamental biological questions related to bacterial protection molecular mechanisms against stress conditions. 3) Lead and manage research projects, including securing funding, project planning, execution, and dissemination of results both at national and international level. 4) Mentor and supervise PhD and Master students, and postdoctoral researchers fostering a productive and inclusive lab environment. 5) Collaborate with interdisciplinary teams within and outside the institution. 6) Contribute to the scientific community through peer-reviewed publications, conference presentations, conference organization and participation in scientific committees. 7) Manage and coordinate the ITQB NOVA research infrastructures. 8) Teach at a postgraduate level (master and PhD); 9) Actively participate in citizen science and science outreach activities. Scientific Profile Required: 1) PhD in Biochemistry, or a related field; 2) Large experience as an independent team leader; 3) Proven experience, demonstrated through publications, in structural biology, particularly in studying protection molecular mechanisms against oxidative stress, preferably with a focus on bacterial enzymatic systems; 4) Track record of publications in international journals, namely as corresponding author; 5) Demonstrated ability to secure national and international competitive research funding; 6) Experience with X-ray crystallography, SAXS, cryo-electron microscopy, biochemistry, biophysics and X-ray fluorescence imaging; 7) Experience in managing and coordinating research infrastructures. 8) Strong leadership, mentorship, and collaborative skills; 9) Excellent communication and organizational abilities; 10) National and international teaching experience; 11) Fluency in English and Portuguese (spoken and written). Rationale for Hiring:The hiring of an Assistant Researcher with specialized expertise in structural biology, including X-ray crystallography, SAXS, cryo-electron microscopy and X-ray fluorescence imaging is fundamental. The primary focus on investigating bacterial molecular mechanisms in response to stress conditions, particularly radiation, is essential for developing novel protective mechanisms against stress conditions and that could be applied to different organisms. The candidate´s unique combination of skills in structural biology (X-ray crystallography, SAXS, cryo-electron microscopy), biochemistry, biophysics, and X-ray fluorescence imaging will enable breakthrough discoveries in understanding bacterial protection mechanisms against stress conditions, notably radiation. The multidisciplinary approach, starting with the study of protein targets and expanding to a cellular perspective, aims to comprehend the role of these targets within the cell.  Furthermore, the selected candidate´s extensive knowledge across various areas of structural biology and X-ray fluorescence imaging will be fundamental for promoting these fields both within the host-institution, ITQB NOVA, and at national level. This will ensure that ITQB NOVA will be an unique center with comprehensive knowledge and expertise in these areas. The selection of a candidate with a proven track record in securing funding and leading research projects will ensure the sustainability and growth of our research initiatives. This role is essential for driving forward our mission to contribute to global health security, thus reducing poverty and inequalities.