PRR Project

Summary

Job Description: We are seeking a highly motivated and skilled Researcher in Molecular Mechanisms of Metabolic Diseases to identify novel druggable therapeutic targets and nutraceutical bioactive compounds with therapeutic potential, to join our dynamic team at NOVA FCT/ UCIBIO/i4HB . The successful candidate will be responsible for conducting cutting-edge research in the areas of Molecular Mechanisms of Metabolic Diseases and Identification of Therapeutic Targets, with a specific focus on Diabetes and associated Metabolic Diseases.Key tasks include discovering novel therapeutic targets and identifying pharmaceutical and nutraceutical bioactive compounds to modulate the putative disease targets, interfere with disease mechanisms and test effectiveness in preventing or curing the disease in question, designing and executing pre-clinical studies in rodents and designing human interventional studies and clinical trials. The researcher will contribute to the advancement of scientific knowledge and the development of innovative and sustainable solutions in the field.Responsibilities:Conduct clinical observational studies in humans to collect biopsies and patient information.Design workflow for analyses of human samples using advanced omics and microscopy techniques.Analyse and interpret omics data to identify novel potential therapeutic targets.Design and execute experiments to decipher protein signalling networks involved in disease mechanisms.Investigate molecular mechanisms of interfering bioactive compounds and optimize experimental protocols.Conduct in-depth analyses of molecular signalling cascades using advanced characterization techniques to decipher mechanisms of diseases with the objective of discovering new preventions and cures.Set up and execute pre-clinical studies in rodents to test therapies on proposed therapeutic targets.Collaborate with interdisciplinary teams to integrate findings into broader research initiatives.Lead publication of research findings in reputable scientific journals.Stay abreast of the latest developments in Molecular Mechanisms of Metabolic Diseased and related fields.Scientific Profile: The ideal candidate will possess the following qualifications and attributes:Ph.D. in Biomedical Sciences - branch/specialty Morphological Sciences, with strong documented focus on Diabetes.Proven expertise in deciphering cell signalling processes relating to metabolic diseases and diabetes, and expertise in experimental design to decipher molecular signalling pathways with a track record of successful projects.Extensive knowledge of advanced microscopy techniques.Proficiency in utilizing bioinformatic analytical techniques for high-throughput data including transcriptomics, proteomics and metabolomics.Strong publication record in reputable scientific journals, demonstrating the ability to contribute novel insights to the field.Excellent communication and collaboration skills, with the ability to work effectively in a team environment.Rationale: The recruitment for this position aligns with the strategic goals of NOVA FCT/ UCIBIO Research Unit to advance research excellence on thematic line TL2 (Diagnostics, Drug Discovery and Development) dedicated to finding innovative therapies for incurable diseases through target characterization and identification of new biologically active molecules, contributing to sustainable health strategies. The intersection of acquisition and interpretation of omics data, with clear validating strategies, integrated with novel uses of nutraceutical bioactive compounds represents a burgeoning area of scientific exploration with promising applications in drug discovery, novel nutraceuticals, and sustainable health interventions and technologies.The expertise of the successful candidate will significantly contribute to ongoing research projects and strengthen our institutional capabilities in these critical areas. Furthermore, the hire will enhance collaboration with external partners, foster academic-industry relationships, and contribute to the training of the next generation of researchers in Disease Pathways & Biomarkers for Diagnostics, Drug Discovery and Development. This position reflects our commitment to innovation and scientific leadership, positioning NOVA FCT/ UCIBIO/i4HB at the forefront of advancements in Disease Target and Drug Discovery and Development and related disciplines.